	   SnapGene      ÞGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCGCCACCatgcaggtgaaaaatataagaaagctcccctgccaaattattcaatcagttggcaaacatgaattgactgggcataaagtagctgtgaagatactcaatcgacagaagattcggagccttgatgtggtaggaaaaatccgcagagaaattcagaacctcaagcttttcaggcatcctcatataattaaactgtaccaggtcatcagtacaccatctgatattttcatggtgatggaatatgtctcaggaggagagctatttgattatatctgtaagaatggaaggctggatgaaaaagaaagtcggcgtctgttccaacagatcctttctggtgtggattattgtcacaggcatatggtggtccatagagatttgaaacctgaaaatgtcctgcttgatgcacacatgaatgcaaagatagctgattttggtctttcaaacatgatgtcagatggtgaatttttaagaacaagttgtggctcacccaactatgctgcaccagaagtaatttcaggaagattgtatgcaggcccagaggtagatatatggagcagtggggttattctctatgctttattatgtggaacccttccatttgatgatgaccatgtgccaactctttttaagaagatatgtgatgggatcttctatacccctcaatatttaaatccttctgtgattagccttttgaaacatatgctgcaggtggatcccatgaagagggccacaatcaaagatatcagggaacatgaatggtttaaacaggaccttccaaaatatctctttcctgaggatccatcatatagttcaaccatgattgatgatgaagccttaaaagaagtatgtgaaaagtttgagtgctcagaagaggaagttctcagctgtctttacaacagaaatcaccaggatcctttggcagttgcctaccatctcataatagataacaggagaataatgaatgaagccaaagatttctatttggcgacaagcccacctgattcttttcttgatgatcatcacctgactcggccccatcctgaaagagtaccattcttggttgctgaaacaccaagggcacgccatacccttgatgaattaaatccacagaaatccaaacaccaaggtgtaaggaaagcaaaatggcatttaggaattagaagtcaaagtcgaccaaatgatattatggcagaagtatgtagagcaatcaaacaattggattatgaatggaaggttgtaaacccatattatttgcgtgtacgaaggaagaatcctgtgacaagcacttactccaaaatgagtctacagttataccaagtggatagtagaacttatctactggatttccgtagtattgatgatgaaattacagaagccaaatcagggactgctactccacagagatcgggatcagttagcaactatcgatcttgccaaaggagtgattcagatgctgaggctcaaggaaaatcctcagaagtttctcttacctcatctgtgacctcacttgactcttctcctgttgacctaactccaagacctggaagtcacacaatagaattttttgagatgtgtgcaaatctaattaaaattcttgcacaaCTCGAGTACCCATACGACGTACCTGATTATGCAACTTATCCTTATGATGTACCTGATTATGCTAGCTATCCTTATGATGTCCCAGACTACGCATAGTGAGGGCCCGATATCTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAGCTGACGTCCTTTCCATGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGAAACGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCAGATCTGCGCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGCATCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGGGGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTCGACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGG  A½                    *   (      !            $   !   -                   0   '         !      %   &               '                        #         #                        !   (             1      $   0      &      *      "      &      %               #         !   "         !   $   "   (   @   +      &                   !      %   -      !               !   $   '         (   '   %                                                      (   '   )      &   /   (   '                  +   &                            &      &   $               #   (      #         '      $       6   0   !      *   -               &   '   "      $      (   !      %   &   #            #                                 &   2   )   $      !      +   $                $               %   '   #   +                "      2   "      .      '            1   %   &   )       +      +         -      .         Y áìh
Ð
ù
ÉÊ;oÂçðñ•n¿g*gë	vø¬èú  á xâ b@§%<ˆ
ú
3ËfoFK_ÎìIwùöÑ¡@«x, Z ÷ í&<£ò£ÕÂm½h
­RÀû   ÈN’ñc	i
Ñ
Þ
²Ip°Ãè–èˆÀ[h+ºŒ>¥é€ t û c1·ºäs\!
Ìâßë	qùx¢-ˆ* ´BªØÂ¨&*>Š®vÄ«
û
ÃÞîò9±ÈGý“ÁóJ)¯÷,½ýAÚay‰( ÎãžàA„ØJåú=	¿	(¦gp06Qmùc¦ÚíúÜµŒÒí¬ùÓ' â y!½&‰
Ë
4\'øLÆÒ`Ï‘ ! ø ¬_±Æ¤%†�#B
ð
 ¤!ÖÃnä�¾€&Ïå_†bS Œ MR’>Ù›	óÊßo‰®Ä8Y™ ´Õî³àŽ
d
=$¤Üü]Èi¶$i€çb®ã"Áü [ f†(n'BPµµ,®Ù5ðB‹$  ÉOVñ•=
¨
Ä
Á\«N^vÃúýª}�ÃÜBƒ¢ÿÌ¾Š ê�! ]‡ºôjSò6a5
j
ß
NÇ—¹à(‰þi¡GT~(e´- œ {Üžoî	Ò
×
wÏJ±é|Ô—âôv~™²Q�®Á,G¹Þ»Ö½P?ó¦Ûž¹    “ TÑ“Äd	)
Ml³qªËéw´ºîešµk$6è² d¸×�Ö$ma	
Í²¸Ýàì4tüa{~ÂR£‰ O»0t6Üãd*rŒ•yßË{	. u ü ÓÐ]	"
¡Qú~Ø3+IÁe‘’ t˜2½åoŠÊ
éí"ô[¤îÆa¾VÏ�0 )Ù¶Ã3�ú!'�Ee‹«¯‚Åü
ßï§ä,ÕAH_þñô°øàý•þBb³Í' ÉÔCQäê7>r@Ïç+w�	Ä×ÉŽÜ”p²ÊK†-„ÂÛíŠê µý«ÔX‰¯v}?†²Ó¤²ì‡ Âfò}z’ßÐ Y“©í¬
ó:Hð:	*K¾Ã!  ¯9§áM|ƒ=ô÷±
gÞ-	K	Ù1N¢¡úyÛQ\ % Ï™aÝ6 lYæi	À	Yõèû›Ý“œÃ­Ô% 7 ä,Æ2hÆfðŠ¥€ûa	6	€	“	)ªÐ]hq�DR§-—�¶yÓáâ& ŸB…ÙK´8>P§Ú$7n¼dÞîB�˜ îúc¸Êøú/(08 ¹ Å î AJûE	U
5ž ùù5[N�Ð^q³$ 1 %˜»q	Ì
å
å,’Ó�Ž:„Â > ã zÚ"¿'£T	—	Š
(›„M¯a§’“ƒ^F   « p¾Q™²¿]f3Á×ÛÑoÇ	uy˜Ì]Í�¾' ù Ì`¯²<&œê‚ã½	'
;
@
î
"æ%¯Æo‘³Ág�ýãæ`»„ ­Ç¥‡;d¹_—_	�	¥1×ÛmæÈP\cT #Y­$¥áC
L
ñ
!¶¸Ä«¿Æþ'CŽ‡‚�ƒ "ãE
°å/bU»EÐ¹×Î#— S?ÚlêãØ)É9Z�O” M � Õ N2Ð¹&’­ à/pŠ¯-KM È þ %•Ê	hœ	Ö	ê	
ôç/’~Ž‡ËÅ#š„ãp  3j‹¾[“€ŽÕ§		0	ógN# . ñ™Wá�¯ª	
$
.
e
Û
ó
#8Û·d.<5|:loÔü
“�…   C ~ ïÙC%€¾%Ðè#Ì>ZÃä#Âg  µÖ‚´…N
+€ý;Çj¿�E¥cka•L# c w Ì øæ*/>Ÿu¥Ý/€^­É ?Sjü¹Ç"0TÚqR¯áý /îNö
£(V¿
j•FR¶-‹’!CŒ \ ¼ ñ D›þ‡HÈ1
z
†º H¶Ò;v¶zÚ‰ÿAs£ íg±ôo4Ò
‹QŠy¯6h/È ¨)DN	8ECÍUànä€ñ ²ÓP©
1Zj}9ÅD©¬Äû]ét~ÁÈÝÍ]áˆÑ  –¢]Úë_wþnÄ„ÀaÉ¿‹ë‚›  , | ÊW€ò£>
‰~/Ù«,…:C£û¡J!  /ùßþ*DLºÂ'1OQ5ç1rŽ¯½ de¶™( ˆ»qÃLÎç~Tb¶È×á,Ýá%)¯Z¼õÿ)j2¢¥»sv�
)À  Hõ\/qGå	6
X
ë3Lû¤1Ho¾ëgÙXfpŸµ ^k7Z	k
˜ðô8<@²ä$S77N\÷^c17¶bÉ P°óÀúG
à
OºVŠïGU,%1  � Ýe­{1äjÅ	
R
Å
È
Ø
ÿ
qKäŒ˜š³,Rž¯ºî×ö¼[¬¾?;@aV»� ¡|¿+<	@	¸	Ý	@Ðû7ÌwUÂËß ÒôExª$  ŽbIûÈ	ã	ï	‘
[}²ãõi¸€žö¼¦>˜ÕG§ŸT}ºÖ0 všØŸp­	~
Ó
x²êR‹Õ�1ƒ-H'×3� ±ÑQt³¿4<¶ÔÜŽ©è–ÐWv µ
t´yµ»f¥¨d‰7„›¶$¦Óð7Òú=m_& ! Ú .»à$”„÷Vp
£
!r¹Ñ@pê3C�Wl%›¨öVrF¸l ˜ Y4kýZÐ	¸
¼
m€‘·¿x¾Äï|<F©èfé$* j ” ¤ ² 7Ue=Ò�Åe	*
Á
N—z«Ì FNðZfo{…�ÄçÉW„:VY³œ à ‘¦ð$b	Ï
H¯ï¢ÔeÁ¾J)÷Ð¤ w¿ù" A¶¹Á¼×%Ir)=­[u 
áñÞ/5÷lbÑ(�´ÿ‹ìø` eÅ…Ø€"�
\µ+ÃŠ&  UiÛÐn4
Î©ÊÓß'³¹áíóuýFM|Û#5O¡ËS}½d³¸ sN¼/Ö�#Òn5±)s!ó£z}½×2H% Ó(PXÓé’µ2 ?uDd±ì�Òã+Ô�ñüƒ”|ÂéÏ $ + 1`‚ÅÜ5Ÿk‰7fÝ’	ÙM–šx—àù’áP
/ ¾S	�äeø+‘Ö�Ì "¬éâ^^	¯å$ÚaýâºO¸�Í– L Ô ý 2iŠ½�¸Ôgé	æ.×‘",JNfMo“# B b v ð˜å)VØB„#
ž½Rûc!Ù"4={QY`Â	’f šì§íGMÑÇ¢ÌÿGTEy.r ÒY.CK¹CÙêØ4\~æÇú¿\`àIÐ! pæ.p¿FÖÜï$7Kî#06Möb¤ºruê+¿6Wµž" u�™×a¾d0?	}
þ
ãŠ‹Ë+õŸ¥»ZÐ²:;D¨ç© i 3jüƒœ¸ 6ïX§õùk Úï!(Œ¬Ztàð¨dIL´Ú"4þŠÏëÿ¼÷cv~²·! Ò*Òè_‘Ä14Žž"ˆÑ°½‘	(LÕ ò™Œ1“–OÎ$ !1ëì—·(FLfáƒÆ�Ëå-Ö`�üxá!MqÌ" oŒÖ`û‚›-¾ý
‰î6 BØÿ}/Lõ±ù9qCß´j¨( Õçë^�‡Ð,KY�	Êí5ÿ�³.KûÙ!3˜0‰ê ÞËu@ *ÊËDEåæ?Æ1Ëxñ†		
ÇÈÉƒ„…—˜ýþ• 12jk./…†‡ˆÃèé	ÛÜÝÊÜîZ[hrstëì¡+ � P+JÌãFR@ZÇA
2UÌyçò‡	
�†™–q*>GËl
i‹íõ¢ 	†÷{8vs¸èw”ÅØ5Ê4ÝrL‡JNÄ/ðÝï\ñ& � Â ô GQÅ,KÕAY°z~3V‡ÍÍ	‡³í¦—r!{c
DÀjŒà I ¿ Ý Í¬SÈhwÏèu!ˆ+3Hâí]~¦°{“ªîö  S ¶äþSwŠ»@{Ôíóˆ	è
š¥©ûCŸ?ÌÝ(65£Å O ì!G[™Bs³ zèt	
T‘•Ã¯gómKRÑ ¨ × 8
Æ6¼Ÿoþ¿iµÞ 4øýw”tª¹<oéxÙ;>”IŽÞç
±K]ò¯! … 
7‡|§'îI·þ 	¤	­
ÓË5`uñ;sríÅ0–Äð+ Z9	ê•x	Z
ôENˆM+ˆL„Oñm% r ‘ õ RvªÆL¢¨Ö#„â>±4_ˆì	Ú•O›ûtŽ˜"³œ &@- Ã HnûâVz‹­îõø{²W„Î+	I	
þˆ2B‚îs°ÜdÝ)ÁÈÍË  Ê -:¯B} 9jß.	L	¨	»	´|ˆÇÒ�á! ,c°ÁNZ«Ìùyh	:	Î	Û	éò1:­£¢§UzôEDR†k] J g Ò Þ Ð-bãiçÐ\	Ôö"RÖ4¹My^½÷d ƒ À mÐ
ufmx
3b,Iùü–”î3®|ï & n p *kÎsš­Ê!Þà7Tw¡ÉáZšj	‰é%'«Ù ( JúÜ	Á	éZv´�êãœÞ�Ä§±”šÕ! 4 ; ¶ ë >øBÿÇñ|”	à	m
 
l|ESXëÍ)‰7u×°ÅÆ$ 8 F T _ `—¤åxÇ gA\�œî	7	�	Ñ¦üD%`·zâ3­'  åœÂ3i‹¼V‹‘9ŸüÕ‰	õ	«^ir�› ©˜@PÔlã¸Ûå¤ ·è-Tò¦Úbôž	é
*Uª‰ÏzÍ¨.ž^Þ¤6v ž"9M²
’í8–
áæ¬!9CÄhnv˜�ù)( P 'ÂíŠš£ÞCµ¸t!?u	Ø	%˜&‹Î�9x…°ÍôeåLç¹Ô¼' �•ÌCËaóQ“él	¨ÛKö> oyeï€Ž¡ï[d®û091SrÒ%  Hm\†ÚLÊ´{%	C		
Uöšj”½ßÓëkC™ûu *ËI9  W Š Kß]¦
ÇÜ·ú\åñªŸ©‡% © ©	ŸúO“ì_I‘Àš¶ º Æ ï B“ü	9
6C½sá6ñÊjß * Ø 5FõX	¶	Ã	V
7xü( X¶‚Ñpÿr}´ÒŒ &þº=pÖ3Í
-�ïŽ²Õ;{^ 5•—:™y¼Íür	„	æ
æ<•JŒ“(<EÛåhLóP­°Ã 2 � l�ÀùTxu«ßÔè#Æ»× �RêËÚ:?ã�÷… }÷(˜	I
a
â
Ô6…ò>N<°Y7¤ž«.>_, ? ¤¨JU	¥	œ“sîù— † ä {ƒ#ˆÂïŸ!	‹
<Ì”1Å@ Û8(ÀÆ.¤¸ÿ®
Q)Aavõbt¨ÕÆ„iñ–œG ¡ •ëa4ØÈ
v£’,Ù^SÆØŽ³ ¿ §¾‚’²ëF^×ìRÞs
OÒÕzžPA«ònF q[:¿¡»Žš³À	2	y	v
$^¼Ü~Å‰™Nà&õW ¬ ó£
Lü–	[
õ\g‘–ÂFpâ‰ÍM…Î' ö wÇMaë?g
Ý
±%næçml‡Z¼f¹‹=Q( s ú Í³©×ßãƒ~‰äùÃ~	¾	Ê
'Â&8°ÇêPpü’¥Ùø®¼Ù‡' «‘°=£
$'m…²ßš	
A
c
ï
 #Û~�#h´­ä
7XaØ4…˜!aA) ’ › S\†¹zó�R”5`í	(
<
M–Pœu™´ÂÝù©A‚þ ç±�' ÕÏlÛ`	
‰ÉÜ3Z}Þ*QdzUÎ‘& Èüã6=WˆqŒ®ù|€Îæ…Ž	Ö¦Gëï@ð±Éeß‘²ÞÌ/ 6 ®8˜¦ÅLg{<eïóö¤°³X	`	,	5	J	ÏØô\Ž#C¡ »çÝAŸÂÉ.[( 0 = Ÿ ¸ Ä í @IoÙúD¾º˜¢±–	T
ä
ÿ2
šƒnMt¦]²9‚]½' ®;›!:c¸–àâŒ	¼	&
D
K
®µ·Å.²ÀfÅÇBDÖ[€‚  $ZÏÉ%k‘¦/	Õ	
}�ÿ(È�ƒâ Ë ÷®©	M
Ú
ò
"..¬>¾ÏÆj9nÓŽ„ .°C~3M	
0
y
õ
U¹µÑß:u	m‰Qãgˆþ@Ç  ±¢.|Þ&¨+0„®À¼cd‡˜ ÂO[¯Í}äù	F
êó2;®úUô£±[]Fn½Ø0$È+  H¬úzã*i;	¬	Ç	Ü	â	
Q
Ç
?p±œ0T‚íõ>ÑFºwS•ÏVu|Õ& -dß#YUÏ	o
¢
»
À
 sÐ?Ã¤æcˆÈV{ƒŒ9VÑ~<qE›l^  ß T@<î¡ÓÀòN*ÊøÙ .ÛjCmëÑ÷¢ûø‘Gè A K a Ó ™¦äè]	®ä#þFSÙbzP_€e• h Ñ~ciE>	ÕJ×5žº¹:[æ¾ n‹ÑÑ�0'c‹ÎLN}i§  Ž O…zY·	“ð
4�‚-Jú0—.ïÉð H N Á vºgyìÌ	 ¨ž ®'báJ5\4¯ „ Ö 3n¶£	Ò“ž_týq°ì•& q É +bu®"ªËáø8x
^iƒ	*	9	H	§	º	ë	
ýè0¬�¯Æ(›%…? ' o jlÏtÉßIâÛ
a�•$&& : E ÿ =–£ç›ÁñÿU�[›ž�	ß	Ÿ
T{¨ÎyWêˆk2¬¯ÄÚä$ &Ë¢ÊòL$	B	k	×	õJ	“ŠÍ B„ÒÌêju—äZæ»q  ) V ‰ 4’\¨	W	µ	Â	Bw'¶µëäð|©™ž¨ € kŒ¿�9Õƒ	9'ÔözÅÖO¬ ‚Åö-ô=h?•› ¦”�K]ÖûÝ�		1	ê[Äá‘�Øß%@ªÅ²ÿ# …¸�òlQ“Þ}f
Ü
°$ml}ékYÜø¸¨Š	6×3—Ø†( / 5 < · ì ?ØùC 7Ä5Kpò¯ ¡°Ú•	Î	[FºL|Þ@ž�±Ý¼ 
šÈ�‹	Ô	
%
/
ô
--Ð9elÎi8mÕýÆ# 
 Xâ¡Tø«	á	
P
n
¡
¿
>ùT%�‚ì*/ƒ=m};cpv”šÇ  ` ˜h;BD ­Ò¿ýE¸åçØ G „Šy�/X¶ ï¢	Ë	�’�§&aÍI4[Èh¦' 9 D atæÈðþ]‚�Úñ	#	)	8	G	
`§«ƒÑéi–ãå$®ºÃ U  ˆ ¥8ÄŒ‚	´	&µ&×${?©Ä<þ>$ 	 ·×	Ã4koP’ ÙŠ	Ó	O
¯,ZkèøÏk‚hl�Öb–Ü  ƒŽý.Wµ7:³	Ê	
Ÿ¬´_‘œ¦ª äÇ=¹æ¥6  ¶d�jŒ�,-nªÖ×Ø²	ö	‰þÿYj¡¢£¤¥åæç÷ÍÎ ÈQRSTFGdefg¤ÕÿV<¤¥0 æ }æ%ežr½ÐŒ«ý†ñ	÷	ƒ
�
“
	�ŠW]j s<¡™ÉAUÀ@H¦ë¥mWBM¦	!  ¸.Ž
JŽ”? Xvt={Î@/kš¾ ºó#1)nSíå d éUfŸs¾çcò	0Þ©BVUòr¡¥3C§* óF`+�§¬Û‡¨õŸ	ø	+<‚^kV«Š_Ê¢?ITW¬ý_ìÛ¦7XwâN- x Í ç ~ç&ùÂÑþå	„
”
ê

ae……‹af€¦0�Ð®!ŸÊÁßA”šI§È° þ
 œ/ïÂ:Õ
÷
K¤@¡À“Nu|—÷¿Gi³»ô$*îæ* #ON	o	W¿3Ïç­›–o"D 0)9hkÅS·¹.woŒ‚�“ú!  Ÿ¹�
³
�•´Ynwî>â/A"0:Dlžª2™T�& îVg‹´€¿¤."@d2
{
›»I·'ÏÎõ{V¸M^è¦ 4½K' Q ½ ò EÃÿê^tQ›èIurv	R‡CùA&ÓJy×v‘æºk¤õ¨" ] e (œqˆ ßd¶‘Ù	ó	°
1w™Œªòv†±·Ûs¢BtÒÕ˜Ë Ý¡D¹�Éß<|‘:CWÙ!5¢ÓfÈóÖŠD$ x–Íõa”|	,=zSÜ¬ÁÇ!Ÿ£Xd‹°7e¯YxOTYsÓ �höGŽÓôêì�R@­`œ§i0( p*DÎ5¨­ÜRŠ¦ö 	
ƒŒƒ_+WËJUþ�’zÜ>¢ð:˜ãü1:ž! î²ôÌ,bˆ©m	ù	
©lL÷?‹`pzfðÁí�\8óÉ2I y :Iÿ…
ë
†§cx‚�b¯á¾ËÔ•SÉålD!«õJÿ% è èð'¡©ú*ÃÛÈ0ºV1Ñ• ãoàBìJ6�vÞ'+& nE]ÒMËµ|«&	D	¯	û	þ	

€
9b†Tg"r…àÂ›Ãšüêò¡# Î Ú‡O	æ	•
›
Ff«ºDŒ÷b�›Î×Vk)¨µï†±Ì4:x  X à;‡
ø
2È:¢Á”Ef^ÍêHuõ« ?ªç+ �0ª
[¥ÝíøÅÀòÛ+üˆÒ& ‹ L³ÔQ^AûOÇã´ÉÞæ%nˆÎ^­âï# ðÃ§
Ö
Lkv~Æ	{¸vd}˜±ª­À]¸üÕj¼ÂòFÚ‰Ÿ —	 c·û‹èì`P”íÅ`ÁÊÀ�œ ª£^Û9†ÿo…JÁì  Oh	X©x,œb›·÷7 ª $—P	p	ÀÚ4ÐZ®x€—pŒË\’Œƒ#EÁ ËX¤:
?
í
0ªlåTºü�ƒ" Ç ”1	é	âò¬†.L  - } �-
*t:7ÚÆ-¸;D¤/SËpk”ûàK » ð Cýó7DŠ¾…i”xŠ‘¢   + { 0iˆø8}ý)¡0Pmèqs9~Èµš GKY	W
µà+?Y»(ãR16 €	foa&   ·	Ä	�
Ä
ú6QZh·�Ê&Ö2=�—Ÿ«°s¾Ô3`UµÓ�Ž2 — £ ± Ù 6X<ºö´
·
�–¶¾yÿEMoxïYenz„�½§Ã2B#;Eƒ¥¨ÒUçeš#U·) Äh„µÀÏ¥»Hq#3
Î
G®ÉÒÞ	&.[½ök(EÐö'� ³|_¾$ # r'MWÿ�´Õ>c4e€R	œØâ*°Ó�ð|¼Öw‚àÁ h‰¼«ïŒèU×A¼~D !¹<N·-XLn! /|
X·â-BÛ#J¸ *53åYÏW£¦t_éôø§*5H  0ê_–šî ½às¼œˆ'KÔ×K|w8p’»pö±¶+ )Iâö]uœÅ†0JTvÊXæ…	Æ3–ì4ü)=FqØiIMçÚYgqô $ R ¾ Ü ó FÄ ë R˜rzÎs	ç
SçtúB”¥2zÜ	C¿ì¥©QÄ § 6ü¦&é;Hý	w	7
Y
»=DM�‡ænƒh´l*®  m©Àú¡UyŠ¬íÚ	ñ9”AšTs�ó‡²ÜÇÑCÌÊ f m ‚ Ñ )	r ,vàeù™
	[	2ÓQ³Õ¸éøLx2¼™Øc 3 ^ µ ê _÷AÙ8ô	l
kˆÌO]$_t£uÖ·$ Ž�Ál‰”Ý`·É’±
™ìõ=ix—àå%«8�8wdt­)€HÓ8 Þô¥
ÛûràWð’H�ÉÑ‹† QS–2ÊÌû‹;DÚâä"îgº £ÁžH
`
á
P;@=X6£Ô�ªø- ò½‘¢±E ºër
u
#`�•»}Ô¢RôV×&E% š [yÞ	øÂ}	™	
b
É
&ÁLå7†O¤»eØ÷@­<Ÿ¬W°`P' ž —<fÔ£½Íåk	4	S
ã
 Õó�™È" ê?ŸïY¥\±8�y-Z�# ~Îöb2·•­
J
x
Ù
T­´Þ-t=±Œ½ÄPÅâAf?Z+  ÞG®|)Æ	º
Æ
->or{ÏÝÂ›óS‡°Ç~‹Z8\­¿Ðb¼/Ut{Ô @ }¥=	íIña�¡ú÷F µëÑŽ^s�ë  <¢iÀ©÷H�KA	¦	¹	Þ	ž
üISzÍx€VÌA®”tYj1> �‘\Ôõ,V	A8ÃàÓïõ¨˜y«" „�6J®ÝÿS ÷ 
¾
=Í,j$€¹�÷K§{Ý?2™~» ‡ s‰ÿÃð‹"	(	F	¡	‚Öh•H¨;ý×2 å |$cqü+mÏ6O©±	É	Ò	ð	
‚
Œ
’
®ˆV\i~ž³XäöÌŸ?êœ£þUÆ;A£"  E_Á§ä	;I`d„�“„`e>HV«½ÿ“™ò(ñ ìä2Ÿ ›Á 	n	Ô
³m¾M2ö.g�©²¸� . Ü]p³ P-cq~�œ¯
QšBø@{IñuØ 4¡ÒÖu�·Ç]ÕjÑô—ÊJ wõ)Í‰¥{	
y‚RëŒ*ÀÆžc›‘À=9—ò�HX' ï9ÙÇ/ª¹®	ú	ý	
š
ª¹SÖbwŒaq„(âR´Âî5…Ý&ªéô3w †
uìzc°Æâe¿·ÌÔñÚm‡EÙû>¬ž –g	b¨¶ÙŠ8Y…+w‹Ê[ö�6À  è	,
ì
„©ä“-R‰K1 z – ¢ ° W;J¶
Ã
h‡µ½÷|5PXdmyƒŽ¼g¦œÉ%¤§Õ<–8TÓæ_TÇ"´n `% " gªƒ³ÔGQ	WF­AÑÚ"}Ò4DäCX&Ÿ ¶ßó÷,WGm& ¦ Û /é(áû¥%Ä…íSÉßW»s›ºÅ2Ö{†
pm7‚B³o)) l ´ Ð é ¨ö@¿“+‰Üì_ÈØø˜		jÒëPh‡“–ËrŽKw¬(sÐG  ñ¢¼•Ÿ1_
q
t
¤
"_�”úqÓ¡áíœ©QÐ¹+ ™ ZÝ;FÓ¢¼Ì¶¬Á	3	
w
¹
%nÀÎòÝés†Æ}ŠÃO[¬ÄÏá€z ;€[´�
HHy]rðêöX=+ r5^lÀþNþ'	E	°	Ñ	ÿ	�
½
:H_c’­‡Udh�#=Gªéñg'›ýë¢ \oO}�›z	ü	™
P�™¸½¿Åášœ·%ó • ¯ Vf	ç	+
Â
g¼ö{OƒWlÅXã*;ŠQZ†ˆ�5- k ¥ ³ Ï fõ?¤ÓˆžÇ—	P	^
E^iŽ“š¬ùÄÐÙ!g|†’Êq…	µÏ²Ï( :ÜNý˜
œ
GO˜¬ÍGcœñG\qèZ«¶Îð<y. ­ ® 89ô>ÛMÆ\
]
–
—
»]h�’—˜™ø‚ÃÏØ [p‘WXY©ªNOP‡´ÍÎ;  1z  ›GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                ,                                                                                                                                                     	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 	                                         	                                                                                                                                                                                                           )                                                                                                     
                     	                                                         	                              2            
   
         	      	               
                           
                        	                           1         "   !      &              �   x         i   g                c                                                                                                                                                                     ,                                                                     	                                                                                                                                                                                                                           	                 	                                                                         )                                   
       	                     	          2    
 
   	  	     
         
        	         1   " !  &      � x   i g      c   }�  ~Ñ  ~í  +  ƒƒ  ˆÝ  ‘7¿×q»_
»àk 5‰»,
_
Â
cnÀEhš›ºGŽ©Éäm-Óêƒá)#eÉ¦n%u5¤ÛÿŒ°]” Uú¸[±818818(xÈë3 ” .U²Êb\>
¸
¼
t€ûÈá7Rpë3fµ»³©¯$Hw„1…È:vúªÄƒÿ'Ì
nƒÍ˜ÖnŒƒnƒn˜n©À¡Ss€†GÑ&B¾	ª8$(:>4‚´ÿ VÃ~ÓMjjÖ�ñÅ‚¼b	Êœ¤!õ•Bî/E¬…
Ë¼`í¹ î Aû5NÒŽ•!CÞ&dÅ‰Ã~Z’f’¹ÁäTP%Õ[ÆÏiÞd™´jµR‰Óò‡	™>¢?ï2¹ î Aûñ5Á�Ð ‰* ? ¤t˜E
/íEÎ#E
E# 	c	F ¦%`3ð|<	ñc	E
Þ
ˆåE#ž„ØJt˜c	Ñ
°è+M’¸ Á‹ð8Sô’¿	ÜÓ³#…f|µ|ÔóÓyCKÁ�ÿÙ/’ž1„ØJÄc	òBo¤¹ÔÁä)PT²Û®ü÷âÝ{]qIu�ô÷dË’àð¨í¤
ì
hEF¬­Ð“¶ðer«X\ëáÙl«¤¾l
tty¶ÓØO¸
Ýú	dÙ!äº;®d´\÷Œ¨“r lt˜ñc	E
Ñ
Þ
°èˆå/í+EÎ#ÛËŽ¨í“ðr¥‚‘��!ñ” U|Îó<	¸
Á
mtKz²È@NyÝð%8Vë-3OS|€¶Ó:WÄ?oö›¨¤
ì
h“rð8S’ž A„ØJ¦ÙmcíŒ—íùù
/ w�±
ìà8çX6-hƒWµ Ç¨
Ã:cx‚�Så!t˜ i	?ï÷âÝ2Û#£tÆ
oµò:) v. N¯•!CŒ`. YŽN’¥Ò¯E
Ý%Ž•E-#!C ´¿Ò­Ë:m	|	Ñ&Ók£Ï)Jl‘GôzÜ>‘ÛÞË*4zÄ* úÉ�£…ty¶Ó/Ã
Xhâ*Y_Tµ‰ÁÔ
 	|ó/â*YN•!C‰]q 	Iu{�ôSªN×u�¾@N³îiŠ½�fMz#~Ý#!žA„ØJ=¦6mcíŒíù'Ÿ…ÙK¼ÞB˜úÊ8é5spçFÞ�§±Ý™ ZƒGÁ
%ÀF­ÑD&Ÿ¬í±
Èãd*Ë ­{Å	Å
q¶á,šÿ)R¯2[¬¾a¢¥s») “ T(Ñ’½Äc	d	)
M\²BpªËèÆ²ð†
ÅeÌ†>�¬Æ¤†¤ÖbS¡D¹|óÖD(½\BÆð¶á,ÿ)2¢¥s) ­{Å	Å
qšR¯[¬¾a»“Ü_Èëh–Ž¬(G§ƒ=ÙNú¦
·\ñ¨ ­{Å	µ
Å
jq}´¶Åá,»fš¥ÿ)R©¬¯›û$2¦[¬¾Á7Òa¢¥s»)ˆm_™ ZƒGÁ
†
%ÀF­ÑÅeDÌ&Ÿ¬†>�k˜ô<ä$77c7¯Mg¢¡yQ\÷˜	a
6…Nž«_gª}C ¶,Wmà0ùÚlÉ™it)H³-~š·]JÔkÈYy�á x %ˆ
3K_ÎN	ECÍUŠ K]}ÖI
ú<°’å,;>³Ô-k~šÈY·]yJ�×«è¹N·H
`
á
=X6£�ª-EU
�Ðq³ò‰¡• ¯ VÂ
g¼ö{OWl;19D]étÚ,¥¿²Ða£)¡(§-a�Âf§ò~ƒFÐ	¾4Zi€”pŠ‘ #œ/V–€d›¤§Ç!Ÿ÷X¿{É*°7õ xY^À:H_c’d=Gªñ'ëÙ‹«ßï§HýþbØ­	~
RÕƒ'Q³4Ü©èv1ä	~ Õ 2¹—È%1;m%p¯#>‰Ã\)Ã3�!¯ñ•ÍD¦ƒŒƒ_Uþ’ðã1žÐ¡~Ú¿£(a§ƒF¹—È1;m‰\,¥²a)§-�ÂfòÐµ
j}´Å»f¥©¬›û$¦Á7Òˆm_«èH
`
á
=X6£�ª¹N·-ûâV‹­ø{„î°dËd Ÿò	0©r¡Ü‡%ÿë
J + { 0iˆø8}ý)¡0Pmèqs9~Èµšz – ¢ ° W;J¶
Ã
h‡µ½÷|5PXdmyƒŽ¼g¦œÉ%¤§Õ<–8TÓæ_TÇ"´n `²ÓP©
1Zj}9ÅD©¬Äû]ét~ÁÈÝÍ]áˆÑ 3j‹¾[“€ŽÕ§		0	ógNu�™×a¾d0?	}
þ
ãŠ‹Ë+õŸ¥»ZÐ²:;D¨ç© /ùßþ*DLºÂ'1OQ5ç1rŽ¯½ de¶™@ }¥=	íIña�¡ú÷FŸB…ÙK´8>P§Ú$7n¼dÞîB�˜ îúc¸Êøú/(08  “ TÑ“Äd	)
Ml³qªËéw´ºîešµk$6è²†
uìzc°Æâe¿·ÌÔñÚm‡EÙû>¬žm©Àú¡UyŠ¬íÚ	ñ9”AšTs�ó‡²ÜÇÑCÌÊ  i “ œ Tu{�™×3a¾ÜdžÑj“ü0ƒœÄo?	d	î	)
}
Ò
×
þ
Mlw³ÏJqª±¸Ëãé|Šéw‹Ô—´ºËâîôev~™²+Q�®Á ,6Gšµ¹Þõ»ÖŸ¥»ïZk½Ð$6P²:?X§èó;¦²ÛõùDž¨çk©¹' f m o q ‚ É Ñ )+bmu©jlÀÏú	rt¡®É ",UyªËßáø8IvxŠ¬àâí
eù^iƒ™Û
		*	9	H	[	§	º	Ú	ë	

ý2Óaèñ09Q”¬A�š³Ts�Õ¯ó‡�²¸éøL•ÆÜ$&(x›ÇÑ%2C…¼™ÌØ?cÊº Æ ï B“ü	9
6C½sá6ñÊjßÂO[¯Í}äù	F
êó2;®úUô£±[]Fn½Ø0$È" ™ ZgªÝƒ;F³ÔÓG¢¼Ì¶¬Á	3	Q	
w
†
¹
%WnuÀìF­ÎAzòÑÚ"}Òc°ÆÝâées†¿Æ4D}·ŠÌÔäÃñCOX&[Ÿ¬ÄÏÚám‡ E€¶Ùßó÷û,>W¬žGmzš [yÄh„µÞ	ÀÏ¥»Hqø#Â}	™	
3
b
†
É
Î
&uÁìGL®Éåz7ÒÞ	&.[c†°½ÆâöOek¿(E¤·»ÐeÌÔØ÷ñö'@� ­Ú<m‡Ÿ¬³EW°Ùû>|¬`žP_¾S ¶äþSwŠ»@{Ôíóˆ	è
š¥©ûCŸ?ÌÝ(65£Å\oO}�›z	ü	™
P�™¸½¿Åášœ·%ód¸×�Ö$ma	
Í²¸Ýàì4tüa{~ÂR£‰G „Šy�/X¶ ï¢	Ë	�’�§&aÍI4[Èh¦º Æ ï Bq“üeu�™Å×[a…¾:dØ€¿0¡»"�Žš³À		2	?	y	9
v
}
þ
$6C^½ãsŠ¼á‹
Ë\Ü+6~Åñõ‰µ™Ÿ¥»NZÐ²à+:Ã&;ÊõWDj¨çßŠ©#ON	o	W¿3Ïç­›–o"D  +Ô     ÿ  ³         ³)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M¸92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄŸÙÇ'á¦5é¾˜b~c“›é†/Ñç6H@üfìuµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,N¾¯`ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï�\ C—…wuŸüÎaÃYUUÍÀŠÊŠÙ\À+ôî,gýñö€=g?2®¾«ýÿýJÀ…Ð;4õË ÃCøöMŒÓ€;�o÷3ø“ÚS0Àˆ §3L‡Îw£Ó?“?;êÎ®¿¯«³Ü¬ðêÿ-Nåloê@¯’:œ7ìÕW¡¤`­É =³ødpª³ú‡(÷+©d�îŠõx]í›°¹®¨jeª jÃæ‚•V†¥ÕZ—1ikˆ"-) T¿ÐïôÐÑI�ScnÖ’Ó_B T¿ÐïôÐÑI�ScnÖ’Ó_d¿?åï?oÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ãîšôRHAª��ê�U;ð¢fö«áµÐaÊ³a¡u74+¼<èkaà7]l8îóÈ¯-3@3ð®ª-GÇâð�áaxÐq3lƒƒÜp2¾ŒÓˆìr‹xS@x8æ€Å#À4¾-»~Žøñ&öØ8cXÃ6s¡¼9øý¬}õ1]³lLMÉìðº,m�Åm ìÏOŠÏCµÍ�ÇA»,‡öcã£Å›`�V:®¶Çˆ<8ƒÎmdÊ!š8Q:1`8|ëìŽ§	³Îük4Í³ë›>ºJë„À{€+1X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»XíÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~±Á°»ñ¿æí'[Žá�6JSÒn;øèˆ BÎHÌMV¥9×PÔ:hØQn:  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "Ã<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5677" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4886-5677" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5678-5746" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2585-3379" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="843-1431" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4127-4715" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1747-2175" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2189-2518" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2369-2504" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3555-3676" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5747-5851" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1497-1545" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3773-3779" color="#ffffff" type="standard"/><Segment range="3780-3797" color="#ffffff" type="standard"/><Segment name="-35" range="3798-3803" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3818-3839" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3725-3741" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3749-3765" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="822" maxFusedRunOn="822" detectionMode="exactProteinMatch"><Segment range="733-759" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="822" maxFusedRunOn="822" detectionMode="exactProteinMatch"><Segment range="763-789" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="822" maxFusedRunOn="822" detectionMode="exactProteinMatch"><Segment range="793-819" color="#cc99b2" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  =<Notes>
<UUID>133751de-e061-46cb-a9a0-62e6e87ef9e0</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="9:7:8">2023.7.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  5        ¶         ¶)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M¸92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄUyfÑ�tW–ÒQ©U)jñ™!ñ›±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>p^ÜÖ|ó9‡eTtYW7(*+es ¬/Ð87¸±Ÿ÷ÄÚ õœüÊºú¯÷ýÿõ+?@ìÓ×,ãÙ4n3N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êíc·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ørÇÀFïÆÿ˜,{´�n;†<Ù)OI¸ïã¢"�8I#15Z”ç]CPè|u£aE¸é   !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ! <?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="1316" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="933" maxFusedRunOn="933" detectionMode="exactProteinMatch"><Segment range="1317-1328" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3752-3768" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3728-3744" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3821-3842" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3776-3782" color="#ffffff" type="standard"/><Segment range="3783-3800" color="#ffffff" type="standard"/><Segment name="-35" range="3801-3806" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1500-1548" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5750-5854" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3558-3679" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2372-2507" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2192-2521" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1750-2178" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4130-4718" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="846-1434" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2588-3382" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5680" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4889-5680" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5681-5749" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="3xMyc" directionality="1" translationMW="3573.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="825" maxFusedRunOn="825" detectionMode="exactProteinMatch"><Segment range="733-822" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;3 tandem Myc epitope tags&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  ˆ<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="1" name="R1" sequence="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTCTGTTCCAAATCTTCCTCTGATATTAGTTTTTGTTCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="731-828" boundStrand="1" annealedBases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTCTGTTCCAAATCTTCCTCTGATATTAGTTTTTGTTCC" meltingTemperature="69"><Component hybridizedRange="731-828" bases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTCTGTTCCAAATCTTCCTCTGATATTAGTTTTTGTTCC"/></BindingSite><BindingSite location="761-828" boundStrand="1" annealedBases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTTGTTCC" meltingTemperature="62"><Component hybridizedRange="773-828" bases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATT"/><Component bases="AGTTTCTGTTCCAAATCTTCCTCTGATATT"/><Component hybridizedRange="768-772" bases="AGTTT"/><Component bases="T"/><Component hybridizedRange="761-766" bases="TGTTCC"/></BindingSite><BindingSite simplified="1" location="731-828" boundStrand="1" annealedBases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTCTGTTCCAAATCTTCCTCTGATATTAGTTTTTGTTCC" meltingTemperature="69"><Component hybridizedRange="731-828" bases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTCTGTTCCAAATCTTCCTCTGATATTAGTTTTTGTTCC"/></BindingSite><BindingSite simplified="1" location="761-828" boundStrand="1" annealedBases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATTAGTTTTGTTCC" meltingTemperature="62"><Component hybridizedRange="773-828" bases="CTCACTATAAGTCCTCCTCGGAAATTAACTTTTGCTCTAAATCTTCTTCACTGATT"/><Component bases="AGTTTCTGTTCCAAATCTTCCTCTGATATT"/><Component hybridizedRange="768-772" bases="AGTTT"/><Component bases="T"/><Component hybridizedRange="761-766" bases="TGTTCC"/></BindingSite></Primer><Primer recentID="0" name="F1" sequence="TCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="727-832" boundStrand="0" annealedBases="TCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCC" meltingTemperature="71"><Component hybridizedRange="727-832" bases="TCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCC"/></BindingSite><BindingSite simplified="1" location="727-832" boundStrand="0" annealedBases="TCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCC" meltingTemperature="71"><Component hybridizedRange="727-832" bases="TCGAGGAACAAAAACTAATATCAGAGGAAGATTTGGAACAGAAACTAATCAGTGAAGAAGATTTAGAGCAAAAGTTAATTTCCGAGGAGGACTTATAGTGAGGGCC"/></BindingSite></Primer></Primers>
  ><Notes>
<UUID>554b079e-04cd-46e5-910a-3c8d9ddfc533</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="8:15:15">2020.4.4</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  *T      ú  ž         ž)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M¸92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄuGØp†™Q¶±çPaÆI!ñ›±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°8rú½ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>p^ÜÖ|ó9‡eTtYW7(*+es ¬/Ð87¸±Ÿ÷ÄÚ õœüÊºú¯÷ýÿõ+?@ìÓ×,ãÙ4n3N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êíc·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ørÇÀFïÆÿ˜,{´�n;†<Ù)OI¸ïã¢"�8I#15Z”ç]CPè|u£aE¸é   !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  !H<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5656" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4865-5656" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5657-5725" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2564-3358" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="822-1410" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4106-4694" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1726-2154" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2168-2497" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2348-2483" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3534-3655" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5726-5830" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="798" consecutiveTranslationNumbering="1" maxRunOn="801" maxFusedRunOn="801" detectionMode="exactProteinMatch"><Segment range="733-798" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1476-1524" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3752-3758" color="#ffffff" type="standard"/><Segment range="3759-3776" color="#ffffff" type="standard"/><Segment name="-35" range="3777-3782" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3797-3818" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3704-3720" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3728-3744" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="Factor Xa site" directionality="2" translationMW="473.54" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="1292" readingFrame="-1" consecutiveTranslationNumbering="1" maxRunOn="909" maxFusedRunOn="909" detectionMode="exactProteinMatch"><Segment range="1293-1304" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Factor Xa recognition and cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  =<Notes>
<UUID>70bcc161-158a-4f5f-9630-d4c4e88666d6</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="8:9:43">2020.4.4</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  
Œý7zXZ  æÖ´F !   t/å£àam
K] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷¿Û{ç�´Ýo!è^¶Š¿™ž5ì`C¡.]TÂ ªNã»•ºÛáë)³èÄ¤„3Q;W£+.!)
>NŠÃèÁ€å,ëÔæ¹½T¥Û÷à³ÈG­nÜqÖlÓfð�ë-NÀßã‚k”ë¢äzÅmþuc®°l§»‡z/pAÎ,Êƒáb�ñ·í©F³&G5¿ºÔó`)ò4ÎOa¼#)ûöœ® ]Å�Gwœ~Ó6IÀ$Â³ÞˆZx•«…ÓK„"HÞ"ƒÖ�±4ñB ø£_¤*R¥˜UxA:a§ð"Tm´·²\h]‘œTzsOn�ž¬7X¯.Áh6„ØÄ½¹ƒe&.§èâ+‘™‘ÀUÿ0ú ì¦£ÁYßó8T¹X:›‹uÂrô—·)-iÒ9ÿkÔ °WÙj´ÍÞ´5JÉNÇë¯~’NíQ•C=ÊÀDì|-åD¹”rO™És*ófõ�¨__slÀïÉÙÑ²¶n‡Z!•�Êý¤K’fÂPÄÕ¹G"/¼Ôœ@YOoøç3b{¤NŸ¿€ÎE4•_v§ÕÓSÁ{�¸±½£Q"Äý¬Ö>åC÷RH¾Ú§“bÈ[1§×›¥Æ=þ‘‘Oº(Åk§DqÏïeêv¹4ae¹ëúALœ‚½¨#a{Ê ³ý¾ûÛB…„Òb¬W8‰x’xÖë"{X®¨aÙCµ%Ù!w0¯^Â›ƒñ-|„ß|:óÁO­ÃÀMqÖ)�›XöÄU9WnyÌˆ�Æ�¢wÚìTXã*ÔÂÃÀŽ�ƒ·Š­>9ï…Y=,2¸¡¨kßþ­æéÄfõâÇILÁ‹‹ù‰„«Úì”Á§~íÅ»Ý¶íÉß-”Îíƒ{HGÎˆ
Óm,/×.Õ÷Wr·J¤ çQ×Fáy&ÇWóSÔ¨Óp§Æx–šl}<(9àœ°¤\gÖ;ãî’×=®å+ JDÖPã2´Fkëß´äç4ëÂ	áàM<]‚´u¹Î¾¯1ë�Üûü-³Áó¼DÔ�·tô0J‰ê@é@g«dšYm‘ÇTY¸Níc1ó$ÇaSVAÌºKöÓß¿ÃøåÀ0ÏX
fài¹ Ú×Ë‘Á—Š`³‰ê§«S	7qÁCÐ·'ç>ªqPšØÝL�¾~ýd^]É­ùÓ^ˆeZõi’¸CânZ»ChéÉ¢m!qc�g9àYSƒ•@4aGœDá¸g¤Ñ¤ê3nÊ¸DòŒîY�îËŸ#¦?Ø—´W±ìWÀÁþ‡†ôà­?@¶iÜxÞ¿êåû»í0—…â/T±As ƒ‡qºJ^+<·—ü•¼µ­¯ÀQr¥Ù{ÕeÏÉ÷i\‡à�â“-‰÷ú5Aq{Â,Xð?wœˆp–ê‹”Ë}ùhù=[È
	Ã¥ß"‹1¶tÇz€×€ý™‘ÂûQSËÛ¯†È—ïà>È¶É4
ä$:hR8_‡‡3|´a~ªÏ¹ñ«n^7_ÁÅ]Éè[L�'t»ÉF]Œ±4÷17\a¢Röº,›‰²`6PÕÖ³>M”Fj3½»ºëlgÏ²· „F5!ŸUŒL¨ˆÓœuQ”’ÙÁU–²ÛÒ /?ÍÏ	Âg“ZßYçšÜz$¿¤v‚š¥ÝˆˆœC\Š*·÷ÐÞHH3¨þ=Í·÷þ€&˜¼¾C“·Uù[X�¶ß8;ÿŸóSü-Ç'>_3vn8´ìNÈtñpŠ0@	Œ‰·àaÔÙV¼Áº�<îènâ†³\TïÙkäŒ
®Õ}T/K&<r’ÎK�ÂjÓb¤ï(¡3"x™½(Â�i‘“'×7™Êˆ	§€ß?¡ƒIù©©h¥	×±.(€Å¢Œ:ƒ)Ýwvy“¬-§qyÕ“€¤Á4z 1u Ø,
er`Çº[ïæ1R€d§M©*SÏ”õžÌŒŽµsRb|'3lKHM�Vó+O‰Ä&Fæ™ª·,Ð¡Œf´Gos(µzžEZèQÍ“G™Ôâ¨^LWooƒ%g!l¹7Nê¥–ÎÒÕö7HbS$øTæŽ;¾¾–Aé¥W|,Øæ×BIIˆí¥~¸¡9ÁNnö)mÅ–Èä³òj ½–…ÛSL³@öbš¾`†ÛbîîF¥ìºšâ¦»c}Z�ïÉå£¾‰WÝ9SÍÆ€Ÿ(ÎjÝ¿‹¬gè—Ð>pj¯æ„Ýå¸ˆ,º\Ô#),I™Ïm%z‚¤uó¥–Ï»:GÒYÇPQ4ïÉ])R/L$q~åMÃz0™Ë$Úæþ³™ÖFÐ±ü€Ìîž�Ú�Ÿ¦™k<�†Ì‘^ã¹à¥°ÞR‹¢¼îÌ¥S»èø£˜ø<èOcALŽã¥·1ï‹Ü
8ØUS”Â;8é¨Ú?eš­PÎ´!—Âs¥™³ƒêÓ-#¤Ôj5¹«ªZÕ¹$�Hè=‰?ÿDE°k™j_'¼LöæÁ—q›•üevR¬ï¤6àAƒ=�.”Ò%z)a’²"«¸Ò.¤f²W-Ž{IW] ŠÁ/í¯9@:Ê?7Z¨lt3«ì ñ7å	Â»íëþPZc!ê1]	S`=k(³q^#¦æV®]6 «§§„Š¼GCUŽ×Q>»*Á;ˆW¥HÈe™>`œCQ¨:——A9HÍÚ-$hÏ&Ò;½SIÆv µA7–Ë?;¦._¶@ò©†…hÿ‡¬¨€gh1·íÁJµ·ÍÚ	3^êð;—ñ¢®ŽñûÄ¿�wæ1âFë—2 ¶8LŸûÀÑÙFýøÔóŽÒiÉ¹ÿ|¤4b Á™èU;®ŒBâP›ÌæÕÙñ*½X1–½“#‘"
x¯_K×”‰E66ÉÿîîUPn¼úf¥°•®üLùÜƒ)dåäÀN´P.;HÃ7„éDí:=Ú½é<l@Ó™�Ñ¸4 ÷ý÷\œ¾Ø~ó D¯1WÀ0+ë||Ó©g{ü~•R‹Ë%�e*Z¨¢H3Xšp��õ1(¥é—•ŒªäFÑÝ¢«4·Ç®Í æRmly&¦ûa3”¹+\f§"Ça"Íc;ÐÌ-(�ðÚº`œïŒÐ ÓQñŠ—$æU�3ÜÀm‡ò6DYf5 ãªM’ÏC¹Õ<>î`ÿ[�GÉG(à5ŒûïÕASg™Ôœû:1ÖŠ½ƒõk/ˆ:Ç¥.Á G….)�<Ñb¡…ç¤;"'j÷š:�Ç¼S£J|Qb¥½hÿ à7;æ,F)Ðâ{…Ùù•0ˆ=ŒCJÔv­JðdXÚ,¹–~§óožV Óôø6]Ø©Qy§‹Œ5°æ˜DZ-"
 oÉ&-Õä]ß¬C_äj±'«9áÔw;õÏ!–'Ç‘‰(*dAD    ¶�›�:“£I çîÂ Á‹äà±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  )l<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="0" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2400" maxFusedRunOn="2400" detectionMode="exactProteinMatch"><Segment range="2371-2397" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="1" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2400" maxFusedRunOn="2400" detectionMode="exactProteinMatch"><Segment range="2341-2367" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2400" maxFusedRunOn="2400" detectionMode="exactProteinMatch"><Segment range="2311-2337" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5327-5343" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5303-5319" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5396-5417" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="5351-5357" color="#ffffff" type="standard"/><Segment range="5358-5375" color="#ffffff" type="standard"/><Segment name="-35" range="5376-5381" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3075-3123" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7325-7429" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5133-5254" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3947-4082" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3767-4096" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3325-3753" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5705-6293" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2421-3009" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4163-4957" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7255" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6464-7255" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7256-7324" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="19" name="PRKAA1" directionality="1" translationMW="61151.12" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2400" maxFusedRunOn="2400"><Segment range="706-2304" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MQVKNIRKLPCQIIQSVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¥<Notes>
<UUID>6f488f7b-a083-4bf3-a3a5-de498e6909d1</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-PRKAA1(human)-3Ã—HA-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="21:1:57">2025.7.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              «<StrandColors><TopStrand><ColorRange range="704..732" colors="green"/></TopStrand><BottomStrand><ColorRange range="704..732" colors="green"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
